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Rao, U. S. Mahadeva
- Amelioration of Gastric Lesions by Avocado (Persea americana) Fruit Extract on Indomethacin as well as Ethanol Induced Ulcerated Experimental Rats
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Authors
Affiliations
1 Department of Chemistry, Mizan-Tepi University, P. O. No 121, Tepi, East Africa, ET
1 Department of Chemistry, Mizan-Tepi University, P. O. No 121, Tepi, East Africa, ET
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 4 (2010), Pagination: 303-308Abstract
In the present study, anti-ulcerogenic potential of Avocado fruit extract was evaluated using two different models of gastric lesions induced in experimental rats; 1) Indomethacin-induced gastric lesions and 2) Ethanol-induced gastric lesions. Pretreatment with oral administration of the extract of Avocado fruit extract (300 mg/kg) prevented the formation of acute gastric lesion induced by both the experimental models: further, treatment with the ethanolic extract of Avocado fruit extract for a period of 15 days significantly reduced the ulcer index, ulcerated surface and significantly elevated the levels of glycoprotein contents in gastric juice.Keywords
Avocado, Anti-Ulcerogenic Effect, Indomethacin-Induced Gastric Lesion, Ethanol-Induced Gastric Lesion, Ulcer Index.
References
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- Elevated Singlet Oxygen Dependent Tissue Injury as well as Diminished Activity of Antioxidative Defense Mechanism by Sodium Valproate Clinical Course in Epileptic Children
Abstract Views :219 |
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Authors
Affiliations
1 PG Department of Biochemistry, SRM College of Arts and Science, Chennai-603 203, IN
2 Faculty of Medicine and Health Science, Universititi Sultan Zainal Abidin, 20400 Kuala Terengganu, Terengganu, MY
1 PG Department of Biochemistry, SRM College of Arts and Science, Chennai-603 203, IN
2 Faculty of Medicine and Health Science, Universititi Sultan Zainal Abidin, 20400 Kuala Terengganu, Terengganu, MY
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 6 (2011), Pagination: 307-310Abstract
The study was aimed to determine the biochemical changes in the free radical profile and antioxidant enzyme status in epileptic children before and after treatment with VPA monotherapy. Methods: We have studied the levels of serum LPO (MDA), erythrocyte antioxidants (GSH, GPx, SOD and CAT) in 25 epileptic children before and after treatment with sodium valproate and compared them against 25 healthy children. Results: The results showed that MDA levels were increased (p<0.001) in epileptic children under VPA treatment compared to the controls. Antioxidant enzymes GPx, SOD, CAT activities were decreased (p<0.001) in epileptic children receiving VPA monotherapy whereas no significant changes when compared between before and after treatment with VPA. The level of GSH was also decreased (p<0.001) in follow-up cases of epileptic children receiving VPA therapy. Conclusion: It was hypothesized that the oxidants-antioxidants balance were modified further by sodium valproate in epileptic children.Keywords
Sodium Valproate, Antioxidants, Lipid Peroxidation, Oxidative Stress, Epilepsy, Free Radical.References
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- Hypolipidemic Effect of Dichloromethane as well as Methanolic Fruit and Leaf Extract of Ethiopian Alligator pear (Persea americana Mill.) on Tyloxapol-Induced Hyperlipidemic Experimental Rat
Abstract Views :185 |
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Authors
Affiliations
1 Department of Chemistry, Mizan-Tepi University, Tepi Campus, PO. Box. 121, East Africa, ET
1 Department of Chemistry, Mizan-Tepi University, Tepi Campus, PO. Box. 121, East Africa, ET
Source
Asian Journal of Research in Chemistry, Vol 4, No 4 (2011), Pagination: 574-578Abstract
Background: Alligator pear (Persea americana Mill.) or avocado has been used for a long time as a daily food in Ethiopia because of its nourishing components. In our previous work, we reported that, extracts from avocado are known to ameliorate not only hyperglycemia in diabetic rats induced by STZ. However, its hypolipidemic activity has
not yet been clearly studied. Objective: Hypolipidemic activity of the extracts from leaf by dichloromethane (PAL-I) and methanol (PAL-II), and from fruit by dichloromethane (PAF-I) and methanol (PAF-II), was studied and compared to that of simvastatin. Methods: Hyperlipidemia in rats was induced by single intra-peritoneal injection of 300 mg of tyloxapol / kg b.w.. Studied herbal extracts were orally administered at dose equivalent to 300mg of dry extract/kg b.w. immediately after tyloxapol injection. Results: Cholesterol levels decreased 59.74%, 58.01%, 44.82%, 43.09% and 61.11%, respectively in groups orally administered PAL-I, PAL-II, PAF-I, PAF-II and simvastatin, as compared to the tyloxapol injected group. Triglyceride levels in treated groups had no significant difference as compared to simvastatin group except the PAF-II treated group. Conclusion: avocado could lower cholesterol and triglyceride levels in hyperlipidemic rat.